Jeremy Lavine, MD, PhD
Assistant Professor, Ophthalmology, Medicine,
(Rheumatology)
Northwestern University
Feinberg School of Medicine
Project Title: The Role of Choroidal Macrophages in Choriocapillaris Homeostasis
Perivascular macrophages exist on blood vessels in the retina. In the brain, these cells are important for blood-brain barrier homeostasis, but almost nothing is known about these cells in the retina. We have so far identified (Lavine Labs) that these cells are the second most common macrophage in the retina, exist on small veins, express unique marker genes compared to retinal microglia, and are associated with infiltrating inflammatory cells. We are currently investigating if depleting perivascular macrophages will result in a dysregulation of the blood-brain barrier and if inflammatory infiltration will be affected.
https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=42188
