Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells

Michael D. Flood; Johnnie M. Moore-Dotson; and Erika D. Eggers, University of Arizona. This study was conducted with IRRF support — Erika D. Eggers. (Published August 15, 2018)

In this study, it was determined how dopamine D1 receptors in the inner retina contribute to this modulation. It was found that D1 receptor activation significantly decreased the magnitude of inhibitory light responses from rod bipolar cells, whereas D1 receptor blockade during light adaptation partially prevented this decline. To determine what mechanisms were involved in the modulation of inhibitory light responses, the effect of D1 receptor activation on spontaneous currents and currents evoked from electrically stimulating amacrine cell inputs to rod bipolar cells was measured. To read the full abstract, CLICK HERE

Erika Eggers, PhD, is an assistant professor at the University of Arizona. Dr. Eggers was awarded two years of funding for her study, Testing the Role of Dopamine as a Potential Treatment for Diabetic Retinal Dysfunction.

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