{"id":1615,"date":"2020-07-16T12:03:19","date_gmt":"2020-07-16T17:03:19","guid":{"rendered":"http:\/\/rushmore.wpcolorlab.com\/?p=1615"},"modified":"2020-09-25T17:14:15","modified_gmt":"2020-09-25T22:14:15","slug":"na3-glycan-a-potential-therapy-for-retinal-pigment-epithelial-deficiency","status":"publish","type":"post","link":"https:\/\/irrf.org\/na3-glycan-a-potential-therapy-for-retinal-pigment-epithelial-deficiency\/","title":{"rendered":"NA3 glycan: a potential therapy for retinal pigment epithelial deficiency"},"content":{"rendered":"<p><img decoding=\"async\" class=\"wp-image-2671 alignright\" src=\"https:\/\/irrf.org\/wp-content\/uploads\/2020\/03\/irrf_notext_logo-1.png\" alt=\"\" width=\"152\" height=\"82\" \/><img decoding=\"async\" class=\"alignright wp-image-2732\" src=\"https:\/\/irrf.org\/wp-content\/uploads\/2017\/08\/febs-journal-logo-300x81.jpg\" alt=\"FEBS Journal masthead\" width=\"259\" height=\"70\" srcset=\"https:\/\/irrf.org\/wp-content\/uploads\/2017\/08\/febs-journal-logo-300x81.jpg 300w, https:\/\/irrf.org\/wp-content\/uploads\/2017\/08\/febs-journal-logo.jpg 480w\" sizes=\"(max-width: 259px) 100vw, 259px\" \/><\/p>\n<p>In Sumana R. Chintalapudi, XiangDi Wang; XiaoFei Wang; Yunfeng Shi, Mehmet Kocak; Mallika Palamoor; Raven N. Davis; T.J. Hollingsworth; <strong>Monica M. Jablonski<\/strong>.<\/p>\n<p>Atrophic age-related macular degeneration (AMD) is the most common type of AMD, yet there is no United States Food and Drug Administration (FDA)-approved therapy. This disease is characterized by retinal pigment epithelial (RPE) insufficiency, primarily in the macula, which affects the structure and physiology of photoreceptors and ultimately, visual function. In this study, we evaluated the protective effects of a naturally derived small molecule glycan therapeutic \u2013 asialo-, tri-antennary complex-type N-glycan (NA3) \u2013 in two distinct preclinical models of atrophic AMD. In RPE-deprived Xenopus laevis tadpole eyes, NA3 supported normal retinal ultrastructure. In RCS rats, NA3 supported fully functioning visual integrity.<\/p>\n<p>Furthermore, structural analyses revealed that NA3 prevented photoreceptor outer segment degeneration, pyknosis of the outer nuclear layer, and reactive gliosis of M\u00fcller cells (MCs). It also promoted maturation of adherens junctions between MC and photoreceptors. Our results demonstrate the neuroprotective effects of a naturally derived small molecular glycan therapeutic-NA3-in two unique preclinical models with RPE insufficiency. These data suggest that NA3 glycan therapy may provide a new therapeutic avenue in the prevention and\/or treatment of retinal diseases such as atrophic AMD.<\/p>\n<p id=\"u17183-18\"><strong>Dr. Jablonski is an <a href=\"https:\/\/irrf.org\/\">IRRF<\/a>-supported scientist at the University of Tennessee \u2013 Memphis.<\/strong><\/p>\n<p id=\"u17183-23\">You may access this article <a class=\"nonblock\" href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/febs.15006\" target=\"_blank\" rel=\"noopener noreferrer\">HERE<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jablonski is an IRRF-supported scientist at the University of Tennessee \u2013 Memphis.<\/p>\n","protected":false},"author":4,"featured_media":2718,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,220],"tags":[224,225,226],"_links":{"self":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/1615"}],"collection":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/comments?post=1615"}],"version-history":[{"count":0,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/1615\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media\/2718"}],"wp:attachment":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media?parent=1615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/categories?post=1615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/tags?post=1615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}