{"id":4546,"date":"2021-11-15T16:00:04","date_gmt":"2021-11-15T22:00:04","guid":{"rendered":"https:\/\/irrf.org\/?p=4546"},"modified":"2022-07-19T10:12:55","modified_gmt":"2022-07-19T15:12:55","slug":"2021-loris-and-david-rich-postdoctoral-scholar","status":"publish","type":"post","link":"https:\/\/irrf.org\/2021-loris-and-david-rich-postdoctoral-scholar\/","title":{"rendered":"2021 Loris and David Rich Postdoctoral Scholar"},"content":{"rendered":"<div class=\"text-content style_External_376_27\">\n<div class=\"style_1\">\n<p><b>Peter M.J. Quinn, PhD<br \/>\n<\/b><b>Columbia University<br \/>\n<\/b><b>New York, New York<\/b><\/p>\n<\/div>\n<\/div>\n<div class=\"style\">\n<p><span style=\"font-weight: 400;\">After receiving his BSc at The University of Manchester and MSc at Brunel University, Dr. Quinn joined the lab of Dr. Jan Wijnholds at Leiden University, where he completed his PhD.\u00a0 Subsequently, Dr. Quinn joined Columbia University in New York as a postdoctoral research fellow, where he is mentored by Drs. Stephen H. Tsang and Irene H. Maumenee.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Quinn\u2019s focus is to provide clinically translatable impact using iPSC-derived retinal organoid-based approaches for the understanding and treatment of retinal degenerative diseases.\u00a0 He is currently developing gene augmentation and prime editing therapeutics for the amelioration of the phenotypic, histopathological, and molecular changes in inherited retinal disease iPSC-derived retinal organoid models.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cMy own experience as a mentor allows me to assess the potential of scientists at various levels of their career; in my view, Dr. Quinn is remarkably gifted,\u201d says Stephen H. Tsang, MD, PhD, Dr. Quinn\u2019s sponsor for the IRRF David and Loris Rich Postdoctoral Scholarship Award.\u00a0 Dr. Quinn\u2019s project, <\/span><i><span style=\"font-weight: 400;\">AAV-mediated Gene Augmentation Therapy for CRB1-Associated Retinal Degeneration,<\/span><\/i><span style=\"font-weight: 400;\"> will be explored over the next year. <\/span><span style=\"font-weight: 400;\">Its primary objective is to develop and evaluate <\/span><i><span style=\"font-weight: 400;\">CRB1 (Crumbs holologue-1)<\/span><\/i><span style=\"font-weight: 400;\"> gene augmentation therapeutics that can be utilized in a Phase I\/IIa combined clinical trial.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Quinn and his team have hypothesized that the overexpression of CRB1-A or CRB1-B in their cell-type-specific localizations will preserve retinal structure and function.\u00a0 It is anticipated that the tools developed in the proposal will lead to tangible clinical benefits for patients with retinal disorders.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Peter M.J. Quinn, PhD Columbia University New York, New York After receiving his BSc at The University of Manchester and MSc at Brunel University, Dr. Quinn joined the lab of Dr. Jan Wijnholds at Leiden University, where he completed his PhD.\u00a0 Subsequently, Dr. Quinn joined Columbia University in New York as a postdoctoral research fellow, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":4547,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,320,219,295],"tags":[],"_links":{"self":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4546"}],"collection":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/comments?post=4546"}],"version-history":[{"count":5,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4546\/revisions"}],"predecessor-version":[{"id":4599,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4546\/revisions\/4599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media\/4547"}],"wp:attachment":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media?parent=4546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/categories?post=4546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/tags?post=4546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}