{"id":4634,"date":"2022-02-10T13:21:37","date_gmt":"2022-02-10T19:21:37","guid":{"rendered":"https:\/\/irrf.org\/?p=4634"},"modified":"2022-07-19T10:12:47","modified_gmt":"2022-07-19T15:12:47","slug":"2021-charles-d-kelman-md-postdoctoral-scholar","status":"publish","type":"post","link":"https:\/\/irrf.org\/2021-charles-d-kelman-md-postdoctoral-scholar\/","title":{"rendered":"2021 Charles D. Kelman, MD Postdoctoral Scholar"},"content":{"rendered":"<div class=\"style_1\">\n<p class=\"paragraph_style_3\"><strong>MARCUS J. HOOPER, PhD<br \/>\nPROJECT TITLE<\/strong>: <strong><em>CRISPR-mediated M\u00fcller glial reprogramming<\/em><\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Hooper received his undergraduate degree in chemistry and biology from Eastern Washington University, and then completed his PhD at University of Florida in chemistry and biology.\u00a0 A postdoctoral fellowship followed from University of Washington in Seattle.\u00a0 Dr. Hooper\u2019s research interests have focused on preventing, and ideally reversing blindness caused by the death of retinal neurons following his studies in retinal regeneration and glial reprogramming.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As a postdoctoral researcher, Dr. Hooper has been working in the area of M\u00fcller glia reprogramming in Dr. Thomas Reh\u2019s lab at Washington University in Seattle.\u00a0 Their recent work is significant, and shows that M\u00fcller glia can regenerate functional retinal neurons.\u00a0 The primary goal is to generate visual neurons important for retinal disease. To this end, Dr. Hooper has learned to overexpress transcription factors using CRISPR activation, generate and analyze high throughput single cell genomics data and package adeno associated viral vectors.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Hooper is co-author on four recently published papers, and is currently in the process of writing two papers of his own.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As the International Retinal Research Foundation Charles D. Kelman, MD Postdoctoral Scholar, Dr. Hooper will expand his training by focusing on retinal regeneration and will expand his development of the specific genetic combinations to use CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) activation methods to reprogram cells.\u00a0 Dr. Thomas Reh, who will be Dr. Hooper\u2019s mentor during the next year says of Dr. Hooper, \u201cHe is an outstanding candidate for the IRRF Scholar Award, as he is highly motivated for a career in academic science and is a technical innovator who is determined to succeed.\u201d<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">CRISPR<\/span><\/i><span style=\"font-weight: 400;\">, or Clustered Regularly Interspaced Short Palindromic Repeats, is the basis of a revolutionary gene editing system.\u00a0 One day, it could make it possible to develop cures for chronic disease.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>MARCUS J. HOOPER, PhD PROJECT TITLE: CRISPR-mediated M\u00fcller glial reprogramming Dr. Hooper received his undergraduate degree in chemistry and biology from Eastern Washington University, and then completed his PhD at University of Florida in chemistry and biology.\u00a0 A postdoctoral fellowship followed from University of Washington in Seattle.\u00a0 Dr. Hooper\u2019s research interests have focused on preventing, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":4636,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[250,327,320,219],"tags":[],"_links":{"self":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4634"}],"collection":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/comments?post=4634"}],"version-history":[{"count":5,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4634\/revisions"}],"predecessor-version":[{"id":4677,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4634\/revisions\/4677"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media\/4636"}],"wp:attachment":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media?parent=4634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/categories?post=4634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/tags?post=4634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}