{"id":4969,"date":"2022-07-19T09:57:46","date_gmt":"2022-07-19T14:57:46","guid":{"rendered":"https:\/\/irrf.org\/?p=4969"},"modified":"2022-07-19T15:45:19","modified_gmt":"2022-07-19T20:45:19","slug":"cell-press-emerging-lysosomal-functions-for-photoreceptor-cell-homeostasis-and-survival-26-december-2021","status":"publish","type":"post","link":"https:\/\/irrf.org\/cell-press-emerging-lysosomal-functions-for-photoreceptor-cell-homeostasis-and-survival-26-december-2021\/","title":{"rendered":"Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival (26 December 2021)"},"content":{"rendered":"\r\n\r\n\r\n<figure id=\"attachment_5006\" aria-describedby=\"caption-attachment-5006\" style=\"width: 300px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-5006 size-full\" src=\"https:\/\/irrf.org\/wp-content\/uploads\/2022\/07\/ivan-conte-1.jpg\" alt=\"Photo of Ivan Conte, PhD\" width=\"300\" height=\"249\" srcset=\"https:\/\/irrf.org\/wp-content\/uploads\/2022\/07\/ivan-conte-1.jpg 300w, https:\/\/irrf.org\/wp-content\/uploads\/2022\/07\/ivan-conte-1-150x125.jpg 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-5006\" class=\"wp-caption-text\">Ivan Conte, PhD<\/figcaption><\/figure>\r\n<p><strong>AUTHORS<\/strong>: Manuela Santo<span class=\"s1\"><sup>1<\/sup><\/span> and <b>Ivan Conte<\/b><span class=\"s1\"><b><sup>1,2<br \/><\/sup><\/b><\/span><span class=\"s1\"><sup>1<\/sup><\/span> Department of Biology, University of Naples Federico II, Strada Vicinale Cupa Cinthia, 26, <span class=\"Apple-converted-space\">\u00a0<\/span>80126 Naples, Italy<br \/><span class=\"s1\"><sup>2 <\/sup><\/span>Telethon Institute of Genetics and Medicine, Via Campi Flegrei 34, 80078 Pozzuoli, Italy<\/p>\r\n\r\n\r\n\r\n\r\n\r\n<p class=\"p1\"><b>ABSTRACT<\/b><strong>: <\/strong>Lysosomes are membrane-bound cell organelles that respond to nutrient changes and are implicated in cell homeostasis and clearance mechanisms, allowing effective adaption to specific cellular needs.<span class=\"Apple-converted-space\">\u00a0 <\/span>The relevance of the lysosome has been elucidated in a number of different contexts.<span class=\"Apple-converted-space\">\u00a0 <\/span>Of these, the retina represents an interesting scenario to appreciate the various functions of this organelle in both physiological and pathological conditions.<span class=\"Apple-converted-space\">\u00a0 <\/span>Growing evidence suggests a role for lysosome-related mechanisms in retinal degeneration.<span class=\"Apple-converted-space\">\u00a0 <\/span>Abnormal lysosomal activation or inhibition has dramatic consequences on photoreceptor cell homeostasis and impacts extensive cellular function, which in turn affects vision.<span class=\"Apple-converted-space\">\u00a0 <\/span>Based on these findings, a series of therapeutic methods targeting lysosomal processes could offer treatment for blindness conditions.<span class=\"Apple-converted-space\">\u00a0 <\/span>In this publication, findings on membrane trafficking, subcellular organization, mechanisms by which lysosome\/autophagy pathway impairment affects photoreceptor cell homeostasis and the recent advances on developing efficient lysosomal-based therapies for retinal disorders are reviewed.Ivan Cont<\/p>\r\n\r\n\r\n\r\n\r\n\r\n<p><strong>T<\/strong><b>his study was conducted with IRRF Funds: Ivan Conte, PhD.<\/b><\/p>\r\n\r\n\r\n\r\n<p class=\"p1\">Access this article <strong><a href=\"http:\/\/www.mdpi.com\/2073-4409\/11\/1\/60\" target=\"_blank\" rel=\"noopener\">HERE<\/a><\/strong>.<\/p>\r\n<p class=\"p1\"><strong><i>Cells<\/i><\/strong>\u00a0is an international,\u00a0<a href=\"https:\/\/www.mdpi.com\/editorial_process\" target=\"_blank\" rel=\"noopener\"><span class=\"s1\"><b>peer-reviewed<\/b><\/span><\/a>, open access journal of cell biology, molecular biology, and biophysics, published semimonthly online by MDPI (Multidisciplinary Digital Publishing Institute, based in Basel, Switzerland)<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>Visualizing axonemal  microtubules and the proteins that decorate them, on the outside and  inside, points to how the underlying periodic architecture supports  cilia function.<\/p>\n","protected":false},"author":4,"featured_media":4997,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,220],"tags":[157,158],"_links":{"self":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4969"}],"collection":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/comments?post=4969"}],"version-history":[{"count":5,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4969\/revisions"}],"predecessor-version":[{"id":5011,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/4969\/revisions\/5011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media\/4997"}],"wp:attachment":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media?parent=4969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/categories?post=4969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/tags?post=4969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}