{"id":5293,"date":"2019-03-04T16:06:54","date_gmt":"2019-03-04T22:06:54","guid":{"rendered":"https:\/\/irrf.org\/?p=5293"},"modified":"2023-10-04T16:13:01","modified_gmt":"2023-10-04T21:13:01","slug":"smc1-and-the-cohesin-complex-in-retinal-development-and-disease","status":"publish","type":"post","link":"https:\/\/irrf.org\/smc1-and-the-cohesin-complex-in-retinal-development-and-disease\/","title":{"rendered":"Smc1 and the Cohesin Complex in Retinal Development and Disease"},"content":{"rendered":"\r\n

PROJECT TITLE:<\/strong> Smc1 and the Cohesin Complex in Retinal Development and Disease: A New Mouse Model of Photoreceptor Degeneration<\/em> ABSTRACT<\/strong>: Myc proto-oncogenes regulate diverse cellular processes during development, but their roles during morphogenesis of specific tissues are not fully understood.\u00a0 This study found that c-myc regulates cell proliferation in\u00a0 mouse lens development and previous genome-wide studies suggested functional roles for N-myc in developing lens.\u00a0 The role of N-myc was examined in mouse lens development.\u00a0 Genetic inaction of N-myc in the surface ectoderm or lens vesicle impaired eye and lens growth, while \u201clate\u201d inactivation in lens fibers had no effect.\u00a0 Unexpectedly, defective growth of N-myc-deficient lenses was not associated with alterations in lens progenitor cell proliferation or survival.\u00a0 Notably, N-myc-deficient lens exhibited a delay in degradation of DNA in terminally differentiating lens fiber cells.\u00a0 RNA-sequencing analysis of N-myc-deficient lenses identified a cohort of down-regulated genes associated with fiber cell differentiation that included DNaseII\u03b2.\u00a0 Further, an integrated analysis of differentially expressed genes in N-myc-deficient lens using normal lens expression patterns of iSyTE, N-myc-binding motif analysis and molecular interaction data from the String database led to the derivation of an N-myc-based gene regulatory network in the lens.\u00a0 Finally, analysis of N-myc and c-myc double-deficient lens demonstrated that these Myc genes cooperate to drive lens growth prior to lens vesicle stage.\u00a0 Together, these findings provide evidence for exclusive and cooperative functions of Myc transcription factors in mouse lens development and identify novel mechanisms by which N-myc regulates cell differentiation during eye morphogenesis.<\/p>\r\n\r\n\r\n\r\n

Dr. Martins is an IRRF<\/a>-Funded scientist at the Federal University of Rio de Janeiro, where he is an Assistant Professor.\u00a0 His funded project, Smc1 and the Cohesin Complex in Retinal Development and Disease: A New Mouse Model of Photoreceptor Degeneration, has resulted in a published paper in Developmental Biology, \u201cN-myc regulates growth and fiber cell differentiation in lens development.\u201d<\/em><\/p>\r\n\r\n\r\n\r\n

TERMS:\u00a0 MYC \u2013 an immediate early response gene downstream of many ligand-membrane receptor complexes (Armelin et al., 1984; Kelly et al., 1983) binding to 10%-15% of genomic loci in mammals.<\/p>\r\n\r\n\r\n\r\n

Oncogene \u2013 defined as a gene that encodes a protein that is capable of transforming cells in cultures or inducing cancer in animals.<\/p>\r\n\r\n\r\n\r\n

Morphogenesis \u2013 can be defined as the processes that are responsible for producing the complex shapes of adults from the simple ball of cells that derives from division of the fertilized egg.\u00a0 (On-line Medical Dictionary, \u00a9 1997-98 Academic Medical Publishing & CancerWEB).<\/p>\r\n\r\n\r\n\r\n

To read this paper in its entirety, please CLICK HERE<\/a>.<\/p>\r\n","protected":false},"excerpt":{"rendered":"

PROJECT TITLE: Smc1 and the Cohesin Complex in Retinal Development and Disease: A New Mouse Model of Photoreceptor Degeneration ABSTRACT: Myc proto-oncogenes regulate diverse cellular processes during development, but their roles during morphogenesis of specific tissues are not fully understood.\u00a0 This study found that c-myc regulates cell proliferation in\u00a0 mouse lens development and previous genome-wide […]<\/p>\n","protected":false},"author":4,"featured_media":3815,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[328,219,220],"tags":[],"_links":{"self":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/5293"}],"collection":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/comments?post=5293"}],"version-history":[{"count":2,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/5293\/revisions"}],"predecessor-version":[{"id":5297,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/posts\/5293\/revisions\/5297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media\/3815"}],"wp:attachment":[{"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/media?parent=5293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/categories?post=5293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/irrf.org\/wp-json\/wp\/v2\/tags?post=5293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}