The International Retinal Research Foundation (IRRF) upholds a mission to provide financial support for vision research directly and is committed to sustaining targeted research efforts. Today’s vision scientists face many funding challenges making it imperative that all support options are available to them. Similarly, in order to ensure continued funding for young scientists who are developing their independent research projects, the IRRF must maximize every dollar. The formation of partnerships and collaborations with outstanding institutions has made it possible to accomplish this while producing a collective impact.