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Andrew Browne, MD, PhD Assistant Professor, Ophthalmology Gavin Herbert Eye Institute University of California Irvine Project Title:  An Imaging Assay to Objectively Quantify Dark Adaptometry With a Gradient Photobleach Recovery Assay Rod-mediated dark adaptometry is the most reliable subjective assay of visual function that can distinguish normal aging from early and intermediate macular degeneration.  This […]

Thomas Wubben, MD, PhD Assistant Professor, Ophthalmology & Visual Science University of Michigan Project Title:  Photoreceptor Protection Via Metabolic Targeting of the Integrated Stress Response Understanding the metabolic underpinnings that orchestrate stress pathway activation in photoreceptors is critical to creating innovative, therapeutic strategies for retinal degenerative diseases.  This proposal will identify the link between metabolic […]

Glenn Yiu, MD, PhD Director, Tele-Ophthalmology Professor, Department of Ophthalmology University of California Davis Project Title:  Photoreceptor Reprogramming in an Optogenetic Model of Geographic Atrophy Chronic oxidative retinal pigment epithelium (RPE) damage in age-related macular degeneration (AMD) leads to damage to rod photoreceptors and scotopic function loss in early disease, and later involve cones in […]