Authors: Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert. Investigative Ophgthalmology & Visual Science September 2021, Vol.62, 8. ABSTRACT Purpose: Oxidative stress is a major factor underlying many neurodegenerative diseases. However, antioxidant therapy has had mixed results, possibly because of its indiscriminate activity. The purpose of this study […]
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The complement factor H (CFH) Y402H polymorphism (rs1061170) imparts the strongest risk for age-related macular degeneration (AMD), the leading cause of blindness in the elderly.
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ApoA-l Mimetic Peptide 4F Reduces Age-Related Lipid Deposition in Murine Bruch’s Membrane and Causes Its Structural Remodeling. (October 2017) Martin Rudolf, Armin Mir Mohi Sefata, Yoko Miuraa, Aysegül Tura, Walter Raasch, Mahdy Ranjbar, Salvatore Grisanti, Zouhair Aherrahrou, Anna Wagner, Jeffrey D. Messingee, David Garber, GM Anantharamaiah, and Christine A. Curcio. Department of Ophthalmology, University of Lübeck, Germany; […]
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Myc proto-oncogenes regulate diverse cellular processes during development, but their roles during morphogenesis of specific tissues are not fully understood. This study found that c-myc regulates cell proliferation in mouse lens development and previous genome-wide studies suggested functional roles for N-myc in developing lens. The role of N-myc was examined in mouse lens development. Genetic […]
Read MoreA manuscript summarizing the results of Dr. Seddon’s study was published in Investigative Ophthalmology & Visual Science, (IOVS): Investigative Ophthalmology & Visual Science Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration Investigative Ophthalmology & Visual Science (IOVS), Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration, Daniela Ferrara, […]
Journal of Cellular Biochemistry: Critical role of endoplasmic reticulum stress in chronic endothelial activation – induced visual deficits in tie2-tumor necrosis factor mice. (October 2018: Volume 119, Issue 10) Dr. Lenin is a graduate of the University of Madras, India, where she received her PhD in Biochemistry and Molecular Biology Ophthalmology before coming to the […]
Cholesterol Homeostasis in Age-related Macular Degeneration (AMD). Norimitsu Ban, MD Washington University Department of Ophthalmology St. Louis, Missouri Dr. Ban received his M.D. degree from Keio University School of Medicine, Tokyo, Japan in 2005. He then joined the graduate program at the prestigious Keio University Graduate School of Medicine, Tokyo, and completed his PhD in […]
Photo Above: The Corson Lab Group. Timothy Corson front right. Journal of Medicinal Chemistry. “Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization,” Helesha D. Basavarajappa, Bit Lee, Hyungjun Lee, Rania S. Sulaiman, Hongchan An, Carlos Magaña, Mehdi Shadmand, Alexandra Vayl, Gangaraju Rajashekhar, Eun-Yeong Kim, Young-Ger Suh, Kiho Lee, Seung-Yong Seo, and Timothy W. […]